How, Despite Lower Efficacy, the AstraZeneca Vaccine May Sell More Doses

At 70% efficacy, the Oxford-AstraZeneca vaccine exceeded the minimum required success level of 50%. But, it can be stored at normal refrigerator temperatures compared to Pfizer's and Moderna's vaccines extreme cold requirements, making it far easier to distribute, especially to developing nations which contain the bulk of the world's population. And, partly as a result of that, it is 5 to 8 times less expensive than the other vaccines. 

In addition, the AZ results may be bolstered to 90% by reducing the initial dosage by as much as half, which would not only make it more competitive medically, but also reduce costs further while increasing supply. JL

James Gallagher reports in the BBC:

Interim data suggests 70% protection, but the researchers say the figure may be as high as 90% by tweaking the dose, but comes after Pfizer and Moderna vaccines showed 95% protection. However, the Oxford jab is far cheaper (at a price of £3, costs far less than Pfizer's (£15) or Moderna's (£25) vaccines), and is easier to store and can be stored at fridge temperature, which means it can be distributed to every corner of the world, unlike the Pfizer/BioNTech and Moderna vaccines, which need to be stored at much colder temperatures.. AstraZeneca says it will make three billion doses for the world next year.

The coronavirus vaccine developed by the University of Oxford is highly effective at stopping people developing Covid-19 symptoms, a large trial shows.

Interim data suggests 70% protection, but the researchers say the figure may be as high as 90% by tweaking the dose.

The results will be seen as a triumph, but come after Pfizer and Moderna vaccines showed 95% protection.

However, the Oxford jab is far cheaper, and is easier to store and get to every corner of the world than the other two.

So the vaccine will play a significant role in tackling the pandemic, if it is approved for use by regulators.

"The announcement today takes us another step closer to the time when we can use vaccines to bring an end to the devastation caused by [the virus]," said the vaccine's architect, Prof Sarah Gilbert.

The UK government has pre-ordered 100 million doses of the Oxford vaccine, and AstraZeneca says it will make three billion doses for the world next year.

Prime Minister Boris Johnson said it was "incredibly exciting news" and that while there were still safety checks to come, "these are fantastic results".

What did the trial show?

The vaccine has been developed in around 10 months, a process that normally takes a decade.

• Oxford vaccine: How did they make it so quickly?

There are two results from the trial of more than 20,000 volunteers in the UK and Brazil.

Overall, there were 30 cases of Covid in people who had two doses of the vaccine and 101 cases in people who received a dummy injection. The researchers said it worked out at 70% protection, which is better than the seasonal flu jab.

Nobody getting the actual vaccine developed severe-Covid or needed hospital treatment.

Prof Andrew Pollard, the trial's lead investigator, said he was "really pleased" with the results as "it means we have a vaccine for the world".

However, protection was 90% in an analysis of around 3,000 people on the trial who were given a half-sized first dose and a full-sized second dose.

Prof Pollard said the finding was "intriguing" and would mean "we would have a lot more doses to distribute."

The analysis also suggested there was a reduction in the number of people being infected without developing symptoms, who are still thought to be able to spread the virus.

When will I get a vaccine?

In the UK there are four million doses of the Oxford vaccine ready to go. But nothing can happen until the vaccine has been approved by regulators who will assess the vaccine's safety, effectiveness, and that it is manufactured to high standard. This process will happen in the coming weeks.

It is also unclear who will get this vaccine or the other vaccines the government has ordered.

However, the UK is preparing to press the go button on an unprecedented mass immunisation campaign that dwarfs either the annual flu or childhood vaccination programmes.

Care home residents and staff will be first in the queue, followed by healthcare workers and the over-80s. The plan is to then to work down through the age groups.

How does it work?

It uses a completely different approach to the vaccines from Pfizer and Moderna, which inject part of the virus's genetic code into patients.

The Oxford vaccine is a genetically modified common cold virus that used to infect chimpanzees.

It has been altered to stop it causing an infection in people and to carry the blueprints for part of the coronavirus, known as the spike protein.

Once these blueprints are inside the body they start producing the coronavirus' spike protein, which the immune system recognizes as a threat and tries to squash it.

Why is the low dose better?

There is not a straightforward answer.

One idea is the immune system rejects the vaccine, which is built around a common cold virus, if it is given in too big an initial dose.

Or a low then high shot may be a better mimic of a coronavirus infection and lead to a better immune response.

Are the results disappointing?

After Pfizer and Moderna both produced vaccines delivering 95% protection from Covid-19, a figure of 70% is still highly effective, but will be seen by some as relatively disappointing.

But this is still a vaccine that can save lives from Covid-19 and is more effective than a seasonal flu jab.

It also has crucial advantages that make it easier to use. It can be stored at fridge temperature, which means it can be distributed to every corner of the world, unlike the Pfizer/BioNTech and Moderna vaccines, which need to be stored at much colder temperatures.

The Oxford vaccine, at a price of around £3, also costs far less than Pfizer's (around £15) or Moderna's (£25) vaccines.

And the Oxford technology is more established, so the vaccine is easier to mass produce cheaply. AstraZeneca has also made a "no-profit pledge".

What difference will this make to my life?

A vaccine is what we've spent the year waiting for and what lockdowns have bought time for.

However, producing enough vaccine and then immunising tens of millions of people in the UK, and billions around the world, is still a gargantuan challenge.

Life will not return to normal tomorrow, but the situation could improve dramatically as those most at risk are protected.

Health Secretary Matt Hancock told BBC Breakfast we would be "something closer to normal" by the summer but "until we can get that vaccine rolled out, we all need to look after each other".

What's the reaction been?

Prof Peter Horby, from the University of Oxford but not involved in the trial, said: "This is very welcome news, we can clearly see the end of tunnel now. There were no Covid hospitalisations or deaths in people who got the Oxford vaccine."

Dr Stephen Griffin, from the University of Leeds, said: "This is yet more excellent news and should be considered tremendously exciting. It has great potential to be delivered across the globe, achieving huge public health benefits.